Understanding and Overcoming Obesity

For decades, people have been told that obesity is a simple matter of eating too much and moving too little.“Eat less, exercise more,” they say, as if the human body were a simple calculator.

But after years in medical practice, and countless frustrated patients who did everything “right” yet couldn’t lose weight, I can tell you with certainty: Obesity is not a failure of willpower. It is a hormonal disorder; primarily one of insulin dysregulation.

Let’s explore what that means, how it happens, and what you can do to truly reverse it.

What Is Obesity Really?

Obesity is often defined as having a body mass index (BMI) above 30.

But medically, it’s not just about appearance or body shape. It’s about metabolic imbalance.

When fat accumulates, particularly around the abdomen and internal organs, it becomes metabolically active, producing inflammatory hormones and disrupting the delicate balance of insulin, leptin, ghrelin, and cortisol.

In short: obesity is a state of hormonal chaos, not just excess calories.

Why the “Calorie Model” Fails

For years, conventional wisdom taught that weight gain equals, calories in – calories out.

While thermodynamics is true in physics, it’s incomplete in biology.

If weight were purely mathematical:

  • Everyone who eats 500 fewer calories daily would lose exactly 0.5 kg weekly.

  • No one would regain weight after dieting.

Yet real-world experience shows the opposite. Why does this happens? Because our metabolism adapts.

When you restrict calories without addressing hormones, the body slows its metabolic rate, increases hunger hormones, and conserves fat stores.The result? Weight loss plateaus, frustration rises, and eventually the weight returns. Often with interest.

Obesity is not about energy imbalance. It’s about hormonal imbalance, especially involving insulin.

The Insulin Connection: The Master Switch of Fat Storage

Insulin’s job is to move glucose from your blood into cells for energy. But insulin also has another powerful effect. It tells the body to store fat and stop burning it.

When insulin is elevated, your body is in “storage mode.” When insulin is low, your body is in “fat-burning mode.”

Most people today live with chronically high insulin levels because of:

  • Frequent eating and snacking

  • High-carbohydrate, high-sugar diets

  • Hidden sugars in processed foods

  • Constant stress (which raises cortisol, indirectly raising insulin)

Over time, your cells become insulin-resistant, forcing the pancreas to produce even more insulin.This locks fat away inside cells, making it nearly impossible to lose weight despite eating less.

The Hormonal Web Beyond Insulin

While insulin plays the lead role, several other hormones join the cast:

Balancing these hormones naturally through nutrition, sleep, stress control, and meal timing is the foundation of real, lasting fat loss.

Why Diets Fail

Most diets work, temporarily.

Low-fat, low-carb, keto, shakes, detox teas. They all produce short-term results because they reduce food intake.

But if the underlying insulin resistance remains, the body simply finds ways to defend its fat stores. Common mistakes include:

  • Constant snacking (even on “healthy” foods)

  • Low-fat processed products that raise insulin

  • Diet sodas and artificial sweeteners that trick the body into storing energy

  • Calorie restriction without addressing hormones

Successful weight management requires fixing the hormonal environment, not just counting calories.

The Role of Fasting and Meal Timing

One of the most effective, evidence-based tools for correcting insulin resistance is intermittent fasting.

When you fast, insulin naturally drops.Your body begins to access stored fat for fuel, and growth hormone rises, preserving lean tissue.

Common patterns include:

  • 16:8 – Fasting 16 hours, eating in an 8-hour window

  • 24-hour fasts once or twice weekly

  • Alternate-day fasting, under medical supervision

Fasting is not starvation; it’s a strategic pause that allows your body to restore balance. For many, it’s the missing piece that finally makes fat loss possible.

The Role of Food Quality (Not Quantity)

Not all calories are equal.100 calories of almonds affect the body very differently than 100 calories of soda.

A healing diet focuses on:

  • Whole foods over processed foods

  • Healthy fats (olive oil, avocado, nuts, eggs, fatty fish)

  • Adequate protein to maintain muscle

  • Plenty of fiber and vegetables to stabilize glucose

  • Elimination of refined carbohydrates and sugars

Healthy eating lowers insulin naturally, even if total calories remain the same.

The Hidden Drivers of Weight Gain

Beyond food and fasting, modern life itself promotes obesity:

  1. Sleep deprivation -reduces leptin, increases ghrelin, leading to overeating.

  2. Chronic stress - elevates cortisol, driving cravings and abdominal fat.

  3. Sedentary lifestyle -not only burns fewer calories but reduces insulin sensitivity.

  4. Environmental toxins and endocrine disruptors -chemicals like BPA can interfere with hormones.

Healing requires addressing the whole lifestyle, not just diet.

Obesity and Metabolic Syndrome

Obesity rarely exists alone. It’s often part of a larger cluster known as Metabolic Syndrome, characterized by:

  • High blood pressure

  • High triglycerides

  • Low HDL cholesterol

  • Elevated fasting glucose

  • Central (abdominal) obesity

These conditions share the same root: insulin resistance.

Reversing insulin resistance improves them all simultaneously.

What Happens When You Lose Weight the Right Way

When insulin levels normalize:

  • Fat cells release stored energy

  • Inflammation decreases

  • Energy levels rise

  • Appetite stabilizes naturally

  • Blood sugar, cholesterol, and blood pressure improve

You are no longer “fighting” your body. You are working with it.

The Emotional and Psychological Side

Obesity is deeply tied to emotion and environment. Many patients eat not from hunger, but from stress, boredom, or habit.

Understanding triggers and building supportive routines  is key.Mindful eating, journaling, or professional counseling can help re-align food with nourishment rather than comfort.

Medications, Surgery, and Medical Supervision

Sometimes medical therapy plays a role. Especially for severe obesity or when complications like diabetes and hypertension exist.

Options include:

  • Metformin or GLP-1 agonists to reduce insulin resistance

  • Bariatric surgery (gastric bypass or sleeve) for selected cases

However, these are tools, not cures. Long-term success still depends on maintaining hormonal balance through lifestyle.

The Science of Sustainability

Long-term studies show that maintaining weight loss depends on:

  • Consistent meal timing (no constant grazing)

  • Quality sleep and stress management

  • Social support and accountability

  • Avoiding processed food environments

  • Regular physical activity (not excessive, just consistent)

Sustainability is not about strict rules. It’s about building a lifestyle you can live with for life.

A New Definition of Health

Health is not about the number on the scale; it’s about metabolic flexibility. It’s about your body’s ability to switch between burning glucose and fat efficiently.

When your hormones are balanced, your weight stabilizes naturally, your energy returns, and your risk of chronic disease drops dramatically.

Finally, If you’ve struggled with your weight, know this: It is not your fault. You’ve been fighting biology with bad advice.The good news is biology can be healed. As a doctor, I have seen patients reclaim their health and  confidence. Not by starving themselves, but by restoring the natural rhythm their bodies had all along.


When you lower insulin through mindful eating, fasting, quality sleep, and stress management, the body does what it was designed to do. To restore balance.

Obesity is not a life sentence. It is a reversible condition. Healing begins not with punishment or restriction, but with understanding.


In summary what you should know is,

  • Obesity is a hormonal, not caloric disorder.

  • Insulin resistance is the root cause.

  • Intermittent fasting and whole-food nutrition are powerful tools.

  • Sustainable health means balancing hormones, not fighting hunger.

Your body can heal, given the right conditions.

To learn more about my research on diabetes

visit https://www.oilofdermae.com/pages/research-papers

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